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KMID : 0351219930250020139
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Korean Journal of Infectious Diseases
1993 Volume.25 No. 2 p.139 ~ p.149
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CD4+ T Lymphocyte, beta2-microglobulin and p24 antigen Level in HIV Infected Persons
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조영걸
최병선/김영봉/조군제/강 춘/김성순/기미경/허숙진/김태숙
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Abstract
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We have measured CD4+T lymphocyte, β2-microglobulin (β2-MG) and p24 antigen level in 188 HIV patients. Estimated duration from presumptive HIV infection to last tested CD4+T lymphocyte counting was 55.2*23 months in group with Zidovudine
(Acidothymidine, AZT) treatment (Tx) and 38.4*20 months in group without AZT. There was no CD4+T lymphocyte of less than 400/mm* in 188 HIV patients. Annual decrease of CD4+T lymphocyte counts was 70/mm* in group without AZT tx and 38/mm* in
group
with
AZT tx 15.2 months after tx start. In the distribution of serum β2-MG level in 182 HIV patients and 48 normal control. 90% (43) of control were below 2.0mg/L and 76% (139) of HIV patients were over 2.0mg/L (P=0). β2-MG level was negatively
correlated
with CD4+T lymphocyte (r=-0.394, p<0.001). HIV p24 core antigen was detected in 26 (14.9%) out of 174 HIV/AIDS patients. Of the 26 patients, 21 (81%) were CD4+T lymphocyte of less than 400/mm* and 46% (12) of less than 200/mm*. It was confirmed
that 3
tests mentioned above are useful markers for prognosis of HIV infected persons.
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